Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis
Sophia Krauss, Alexander Zipperer, Sebastian N. Wirtz, Julian S. Saur, Martin C. Konnerth, Simon Heilbronner, Benjamin O. Torres Salazar, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Abstract
Lugdunin is the first reported nonribosomally synthesized antibiotic from human microbiomes. Its production by the commensal Staphylococcus lugdunensis eliminates the pathogen Staphylococcus aureus from human nasal microbiomes. The cycloheptapeptide lugdunin is the founding member of the new class of fibupeptide antibiotics, which have a novel mode of action and represent promising new antimicrobial agents. How S. lugdunensis releases and achieves producer self-resistance to lugdunin has remained unknown.
Topics & Concepts
Staphylococcus lugdunensisATP-binding cassette transporterMicrobiologyAntimicrobialSecretionStaphylococcusAntibiotic resistanceBiologyStaphylococcus aureusAntibioticsBacteriaTransporterBiochemistryGeneticsGeneAntimicrobial Peptides and ActivitiesProbiotics and Fermented FoodsMicrobial Natural Products and Biosynthesis