Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
Patrick Hansmann, Anne Brückner, Stephan Kiontke, Bianca Berkenfeld, Guiscard Seebohm, Pascal Brouillard, Miikka Vikkula, Floor E. Jansen, Mark Nellist, Andrea Oeckinghaus, Daniel Kümmel
Topics & Concepts
RHEBTSC1TSC2GTPasemTORC1AsparagineSmall GTPaseCell biologyPhosphorylationChemistryBiologyBiochemistryAmino acidPI3K/AKT/mTOR pathwaySignal transductionProtein kinase BTuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancer