Galleria mellonella (greater wax moth) as an eco-friendly in vivo approach for the assessment of the acute toxicity of medicinal plants: application to some plants from Cameroon
Mbarga Arsene, Podoprigora Viktorovna, Anyutoulou Davares
Abstract
BACKGROUND: has never been exploited to determine the toxicity of medicinal plants. AIM: larvae as a simple, inexpensive, and rapid model for the evaluation of the toxicity of herbal medicines. METHOD: 24 hours after the injection with the extracts. RESULTS: (g/kg bw) of 3.90 and 4.81, respectively. CONCLUSION: can be used as a sensitive, reliable, and robust eco-friendly model to gauge the toxicity of medicinal plants. Thus, avoid the sacrifice of vertebrate models often used for this purpose to limit ethical concerns.
Topics & Concepts
Galleria mellonellaAcute toxicityIn vivoToxicityWaxBiologyTraditional medicineLimit (mathematics)MedicineToxicologyVeterinary medicinePharmacologyEx vivoMedicinal plantsAnimal modelInsect Pest Control StrategiesBioactive Natural Diterpenoids ResearchBiological Control of Invasive Species