A nanotherapeutic approach to selectively eliminate metastatic breast cancer cells by targeting cell surface GRP78
Jae-Ho Shin, Baksun Kim, Tyson W. Lager, Franklin Mejia, Ian H. Guldner, Clay Conner, Siyuan Zhang, Athanasia D. Panopoulos, Başar Bilgiçer
Abstract
loaded with doxorubicin prodrug was evaluated using a lung metastatic mouse model and demonstrated inhibition of breast cancer cell seeding to lungs down at the level of negative control groups. Combined, this study established that specific-targeting of surface GRP78 expressing a subpopulation of aggressive breast cancer cells was able to inhibit breast cancer metastasis to lungs, and underpinned the significance of GRP78 in breast cancer metastasis.
Topics & Concepts
Cancer researchMetastatic breast cancerCellCancerBreast cancerCancer cellMedicineOncologyMaterials scienceInternal medicineChemistryBiochemistryNanoparticle-Based Drug DeliveryGraphene and Nanomaterials ApplicationsNanoplatforms for cancer theranostics