Loss-of-function <i>SLC30A2</i> mutants are associated with gut dysbiosis and alterations in intestinal gene expression in preterm infants
Shannon L. Kelleher, Samina Alam, Olivia C. Rivera, S. Barber-Zucker, Raz Zarivach, Takumi Wagatsuma, Taiho Kambe, David I. Soybel, Justin Wright, Regina Lamendella
Abstract
R was associated with reduced weight gain in the early postnatal period. This implicates ZnT2 as a novel modulator of mucosal homeostasis in humans and suggests that genetic variants in ZnT2 may affect the risk of mucosal inflammation and intestinal disease.
Topics & Concepts
BiologyDysbiosisMicrobiomeGeneticsGeneGut floraInflammationImmunologyMicrobiologyInfant Nutrition and HealthChild Nutrition and Water AccessTrace Elements in Health