A Sc(OTf)<sub>3</sub>-catalyzed one-pot two-step approach for spiro-oxindole dihydropyridine derivatives initiated by <i>N</i>-olefination of MBH carbonates
Zhen-Hui Yan, Run Lu, Cheng Peng, Jie Tang, Huaying Fang, Gu Zhan, Xiang‐Hong He, Wei Huang
Abstract
An efficient one-pot, two-step, three-component reaction of isatin-derived MBH carbonates, sulfilimines, and epoxides was achieved, thus affording pharmaceutically important spiro-oxindole dihydropyridines.
Topics & Concepts
IsatinChemistryOxindoleDihydropyridineCatalysisCombinatorial chemistryOrganic chemistryMedicinal chemistryCalciumSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques