Effect of hypoxia-inducible factor 1 on vascular endothelial growth factor expression in exercised human skeletal muscle: a systematic review and meta-analysis
Jerónimo Aragón‐Vela, Rafael A. Casuso
Abstract
This analysis shows that both HIF-1α mRNA and protein levels are significantly elevated in skeletal muscle following dynamic exercise. However, the absence of a clear relationship between HIF-1α mRNA and the mRNA levels of its downstream target VEGF suggests that HIF-1α mRNA expression alone may not reliably reflect its regulatory role in VEGF transcription in response to exercise. Given the limited number of human studies examining posttranslational regulation of HIF-1α, its precise contribution to VEGF-mediated angiogenic signaling in exercised skeletal muscle remains uncertain.
Topics & Concepts
Vascular endothelial growth factorAngiogenesisHypoxia (environmental)Skeletal muscleHypoxia-inducible factorsMessenger RNAInternal medicineEndocrinologyVEGF receptorsMeta-analysisHIF1AVascular endothelial growth factor AMedicineBiologyChemistryGeneBiochemistryOxygenOrganic chemistryCancer, Hypoxia, and MetabolismHigh Altitude and HypoxiaAngiogenesis and VEGF in Cancer