Potent and biostable inhibitors of the main protease of SARS-CoV-2
Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi‐Kuwata, Chika Azuma, Miyuki Nakayama, Takato Onishi, Hiroki Nakano, Naoya Wada, Miki Hori, Kouki Shinohara, Yutaro Miura, Takuma Kawada, Hironori Hayashi, Shin‐ichiro Hattori, Haydar Bulut, Debananda Das, Nobutoki Takamune, Naoki Kishimoto, Junji Saruwatari, Tadashi Okamura, Kenta Nakano, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura
Abstract
are potential drugs for treating COVID-19 and that replacement of the digestible amide bond by its thioamide surrogate structure is an effective method.
Topics & Concepts
ThioamideChemistryProteaseAmideCombinatorial chemistryCoronavirus disease 2019 (COVID-19)StereochemistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)In vitroBiochemistryEnzymeMedicineDiseasePathologyInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchHIV/AIDS drug development and treatmentClick Chemistry and Applications