Hydrofluoromethylation of alkenes with fluoroiodomethane and beyond
Sandrine M. Hell, Claudio F. Meyer, Sebastiano Ortalli, Jeroen B. I. Sap, Xuanxiao Chen, Véronique Gouverneur
Abstract
Herein, we report the direct hydro(halo)methylation of alkenes from a variety of (halo)methyl iodides (including F-18, C-13, D-2 isotopologues), enabling the incorporation of a plethora of C-1 fragments into complex biologically active molecules.
Topics & Concepts
AstrobiologyComputer sciencePhysicsFluorine in Organic ChemistryInorganic Fluorides and Related Compounds