Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase
Kavita Gaur, Sofía Otero, Josué A. Benjamín-Rivera, Israel Rodríguez, Sergio A. Loza-Rosas, Alexandra M. Vázquez Salgado, Eman A. Akam, Liz Hernández-Matías, Rohit Sharma, Nahiara Alicea, Martin Kowaleff, A. Valance Washington, Andrei V. Astashkin, Elisa Tomat, Arthur D. Tinoco
Abstract
reveal a promising synergism between the compounds that is likely owed to their distinct but complementary effect on DNA replication.
Topics & Concepts
Ribonucleotide reductaseIntracellularBiochemistryChemistryEnzymeDNA replicationCell cycleProtein subunitBiologyDNACellGeneMetal complexes synthesis and propertiesMetal-Catalyzed Oxygenation MechanismsMetalloenzymes and iron-sulfur proteins