Metal-free approach for hindered amide-bond formation with hypervalent iodine(<scp>iii</scp>) reagents: application to hindered peptide synthesis
Hyo‐Jun Lee, Xiao Huang, Shigeyoshi Sakaki, Keiji Maruoka
Abstract
A new, bulky amide and peptide synthesis with hypervalent iodine(<sc>iii</sc>) reagent/pyridine–hydrogen fluoride complex under mild and metal-free conditions was developed by using α-amino esters with potential activating group (PAG) at the ester residue.
Topics & Concepts
Hypervalent moleculeReagentChemistryIodineAmidePyridineResidue (chemistry)PeptideCombinatorial chemistryMetalPeptide bondOrganic chemistryPolymer chemistryBiochemistryChemical Synthesis and AnalysisSynthesis and Catalytic ReactionsAdvanced Synthetic Organic Chemistry