Markers of Rejection of A Lung Allograft: State of the Art
Tharushi Ayanthika de Silva, Joanne Voisey, Peter Hopkins, Simon H. Apte, Daniel C. Chambers, Brendan O’Sullivan
Abstract
Chronic lung allograft dysfunction (CLAD) affects approximately 50% of all lung transplant recipients by 5 post-operative years and is the leading cause of death in lung transplant recipients. Early CLAD diagnosis or ideally prediction of CLAD is essential to enable early intervention before significant lung injury occurs. New technologies have emerged to facilitate biomarker discovery, including epigenetic modification and single-cell RNA sequencing. This review examines new and existing technologies for biomarker discovery and the current state of research on biomarkers for identifying lung transplant rejection.
Topics & Concepts
MedicineLung transplantationBiomarkerLungEpigeneticsBiomarker discoveryIntensive care medicineOncologyInternal medicineBioinformaticsGeneProteomicsChemistryBiochemistryBiologyTransplantation: Methods and OutcomesRenal Transplantation Outcomes and TreatmentsOrgan Transplantation Techniques and Outcomes