An assessment of thermoneutral housing conditions on murine cardiometabolic function
Xian Chen, Eliza Bollinger, Teresa Cunio, Federico Damilano, John C. Stansfield, Cynthia A. Pinkus, Steven Kreuser, Dinesh Hirenallur‐Shanthappa, Rachel J. Roth Flach
Abstract
Thermoneutral housing conditions cause rapid and reversible changes in mouse heart rate and blood pressure. Despite dramatic reductions in heart rate and blood pressure, thermoneutrality reduced the compensatory hypertrophic response in a pressure overload heart failure model compared with room temperature housing, and ACE inhibitors were still efficacious to prevent pressure overload-induced cardiac remodeling. The effects of thermoneutrality on heart rate and blood pressure are abrogated in the context of diet-induced obesity.
Topics & Concepts
Internal medicineEndocrinologyThermogenesisCatecholamineBrown adipose tissueBiologyBlood pressureHeart rateMuscle hypertrophyChronotropicCardiac function curveAdipose tissueHeart failureMedicineAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesStress Responses and Cortisol