Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges
Chao Wang, Yujing Zhang, Tingting Zhang, Lingyu Shi, Zhongmin Geng, Dongming Xing
Abstract
activity, pharmacokinetics, and pharmacodynamics of these PROTACs are highlighted. In addition, the potential advantages, challenges, and prospects of PROTACs technology in disease treatment are discussed.
Topics & Concepts
Ubiquitin ligaseDrug discoveryProtein degradationProteolysisUbiquitinDNA ligaseComputational biologyPharmacologyBiologyBioinformaticsCell biologyBiochemistryGeneEnzymeProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments