Co-delivery of 5-fluorouracil and miRNA-34a mimics by host-guest self-assembly nanocarriers for efficacious targeted therapy in colorectal cancer patient-derived tumor xenografts
Jianbin Xu, Guolin Zhang, Xin Luo, Di Wang, Wei Zhou, Yan Zhang, Wei Zhang, Jiaxin Chen, Qing Meng, Engeng Chen, Heng Chen, Zhangfa Song
Abstract
These studies strongly indicate that such a nanocarrier-based co-delivery system is a promising combined therapeutic strategy that utilizes chemotherapeutic drugs and nucleotide drugs for enhancing colorectal cancer targeting and synergistic therapy.
Topics & Concepts
NanocarriersIn vivoColorectal cancerCancer researchTargeted therapyCancerIn vitroCombination therapyDrug deliveryPharmacologyChemistryMedicineDrugBiologyInternal medicineBiochemistryBiotechnologyOrganic chemistryAdvanced biosensing and bioanalysis techniquesSupramolecular Self-Assembly in MaterialsMXene and MAX Phase Materials