Alarmin IL-33 orchestrates antitumoral T cell responses to enhance sensitivity to 5-fluorouracil in colorectal cancer
Mengjia Song, Jieying Yang, Muping Di, Ye Hong, Qiuzhong Pan, Yufei Du, Tong Xiang, Juan Liu, Yan Tang, Qijing Wang, Yongqiang Li, Jia He, Hao Chen, Jingjing Zhao, Desheng Weng, Yizhuo Zhang, Jian‐Chuan Xia
Abstract
Our results identified a previously unrecognized connection between IL-33 and enhanced sensitivity to 5-FU. IL-33 created an immune-active tumor microenvironment by orchestrating antitumoral T cell responses. Thus, IL-33 is a potential predictive biomarker for 5-FU chemosensitivity and favorable prognosis and has potential as a promising adjuvant immunotherapy to improve the clinical benefits of 5-FU-based therapies in the treatment of CRC.
Topics & Concepts
Cancer researchImmune systemColorectal cancerT cellCD8ApoptosisChemokineMedicineCancerImmunologyBiologyInternal medicineBiochemistryIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionCAR-T cell therapy research