Modelling the innate immune system in microphysiological systems
Michael J. Rupar, Hannah Hanson, Stephanie Rogers, Brianna L. Botlick, Steven J. Trimmer, James J. Hickman
Abstract
This critical review aims to highlight how modeling of the immune response has adapted over time to utilize microphysiological systems. Topics covered here will discuss the integral components of the immune system in various human body systems, and how these interactions are modeled using these systems. Through the use of microphysiological systems, we have not only expanded on foundations of basic immune cell information, but have also gleaned insight on how immune cells work both independently and collaboratively within an entire human body system.
Topics & Concepts
Innate immune systemImmune systemBiochemical engineeringEngineeringBiologyImmunologyDiabetes and associated disordersImmune Cell Function and InteractionT-cell and B-cell Immunology