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Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

Jacques Fantini, Coralie Di Scala, Henri Chahinian, Nouara Yahi

2020International Journal of Antimicrobial Agents581 citationsDOIOpen Access PDF

Topics & Concepts

HydroxychloroquineChloroquineDrug repositioningMechanism of actionGangliosideLipid raftDrugCoronavirusMechanism (biology)ChemistryReceptorVirologyBiologyPharmacologyMedicineCoronavirus disease 2019 (COVID-19)BiochemistryImmunologyIn vitroMalariaInfectious disease (medical specialty)EpistemologyPhilosophyPathologyDiseaseSARS-CoV-2 and COVID-19 ResearchLipid Membrane Structure and BehaviorNeuroblastoma Research and Treatments
Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection | Litcius