Fibroblast growth factor homologous factor 2 attenuates excitability of DRG neurons
Philip R. Effraim, Mark Estación, Peng Zhao, Daniel Sosniak, Stephen G. Waxman, Sulayman D. Dib‐Hajj
Abstract
FHF2 is known to bind to and modulate the function of Nav1.7. FHF2 expression is also reduced after nerve injury. We demonstrate that knockdown of FHF2 expression increases DRG neuronal excitability. More importantly, overexpression of FHF2 reduces DRG excitability in basal conditions and in the presence of inflammatory mediators (a model of inflammatory pain). These results suggest that FHF2 could potentially be used as a tool to reduce DRG neuronal excitability and to treat pain.
Topics & Concepts
GatingSodium channelGene knockdownNAV1AxotomyGene isoformDorsal root ganglionNeuroscienceNeuronChemistryCell biologyAlternative splicingSensory neuronPatch clampBiologyElectrophysiologyCentral nervous systemSpinal cordBiochemistryGeneSodiumOrganic chemistryPain Mechanisms and TreatmentsIon channel regulation and functionFibroblast Growth Factor Research