NOP2-mediated 5-methylcytosine modification of APOL1 messenger RNA activates PI3K-Akt and facilitates clear cell renal cell carcinoma progression
Junjie Tian, Jianguo Gao, Cheng Cheng, Zhijie Xu, Xiaoyi Chen, Yunfei Wu, Guanghou Fu, Baiye Jin
Abstract
C-dependent stabilization of APOL1, which in turn regulates the PI3K-Akt signaling pathway, suggesting a potential therapeutic target for ccRCC.
Topics & Concepts
Messenger RNAPI3K/AKT/mTOR pathwayCancer researchRenal cell carcinomaCellRNAChemistryProtein kinase BCell biologyMolecular biologyBiologyPhosphorylationMedicineInternal medicineBiochemistrySignal transductionGeneRenal and related cancersAcute Lymphoblastic Leukemia researchRenal Diseases and Glomerulopathies