Diketopyrrolopyrrole-based multifunctional ratiometric fluorescent probe and γ-glutamyltranspeptidase-triggered activatable photosensitizer for tumor therapy
Zhicheng Yang, Weibo Xu, Jian Wang, Lingyan Liu, Yanmeng Chu, Yu Wang, Yue Hu, Tao Yi, Jianli Hua
Abstract
An activatable diketopyrrolopyrrole-based photosensitizer targeting tumor-related biomarker γ-glutamyltranspeptidase was developed, in which it showed specific photodynamic killing effect to HepG2 cells.
Topics & Concepts
PhotosensitizerPhotodynamic therapyMaterials scienceFluorescenceCancer researchBiophysicsPhotochemistryChemistryMedicineOpticsBiologyOrganic chemistryPhysicsNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced biosensing and bioanalysis techniques