NanH Is Produced by Sporulating Cultures of Clostridium perfringens Type F Food Poisoning Strains and Enhances the Cytotoxicity of C. perfringens Enterotoxin
Jihong Li, Bruce A. McClane
Abstract
by increasing CPE binding to cultured Caco-2 cells. This enhancement could be important because many type F FP strains produce less CPE than necessary (in a purified form) to cause intestinal pathology in animal models. Therefore, NanH represents a potential accessory virulence factor for type F FP.
Topics & Concepts
Clostridium perfringensEnterotoxinMicrobiologyVirulenceSialidaseBiologyLysisCytotoxicityStrain (injury)SporeToxinIn vitroGeneBacteriaEscherichia coliBiochemistryNeuraminidaseEnzymeGeneticsAnatomyClostridium difficile and Clostridium perfringens researchViral gastroenteritis research and epidemiologyGut microbiota and health