Prophylactic Erythropoietin for Neuroprotection in Very Preterm Infants: A Meta-Analysis Update
Hendrik Fischer, Nora Johanna Reibel, Christoph Bührer, Christof Dame
Abstract
A meta-analysis update of randomized controlled trials investigating recombinant human erythropoietin suggests improved neurodevelopmental outcome in preterm infants. There was substantial heterogeneity, which could be ascribed to a single trial. Exclusion of this trial featuring a high risk of bias abolished heterogeneity and any effects of recombinant human erythropoietin treatment.
Topics & Concepts
ErythropoietinMedicineMeta-analysisNeuroprotectionRandomized controlled trialRecombinant DNAPediatricsIntensive care medicineInternal medicineBiologyBiochemistryGeneDialysis and Renal Disease ManagementErythropoietin and Anemia TreatmentNeonatal and fetal brain pathology