Influence of Free Fatty Acids on Lipid Membrane–Nisin Interaction
Francesca Saitta, Paolo Motta, Alberto Barbiroli, Marco Signorelli, Carmelo La Rosa, Anna Janaszewska, Barbara Klajnert‐Maculewicz, Dimitrios Fessas
Abstract
-polyunsaturated FFAs (ω-6 linoleic acid and ω-3 docosahexaenoic acid). The results permitted assessment of a thermodynamic picture of such interactions which indicates that the peptide-membrane interaction does not overlook the presence of FFAs within the lipid bilayer since both FFAs and nisin are able to selectively promote thermodynamic phase separations as well as a general lipid reorganization within the host membrane. Furthermore, the magnitude of the effects may be different depending on the FFA chemical structure as well as the membrane lipid composition.
Topics & Concepts
ChemistryPhospholipidMembraneNisinMembrane fluidityFatty acidStearic acidDegree of unsaturationOleic acidPolyunsaturated fatty acidChromatographyOrganic chemistryBiochemistryAntimicrobialLipid Membrane Structure and BehaviorFatty Acid Research and HealthSupramolecular Self-Assembly in Materials