Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T <sub>H</sub> 17 cell expansion
Denise Heise, Alicia Derrac Soria, Selina Hansen, Christine Dambietz, Mohammad Akbarzadeh, Anna F. Berg, Georg H. Waetzig, Simon A. Jones, Radovan Dvorský, Mohammad Reza Ahmadian, Jürgen Scheller, Jens M. Moll
Abstract
T cells treated with IL-6:sIL-6R. Thus, these variants may provide or lead to the development of more precisely targeted therapeutics for inflammatory disorders associated with IL-6 trans-signaling.
Topics & Concepts
Glycoprotein 130Signal transductionReceptorFusion proteinCell biologyChemistryCytokineBiologyMolecular biologyGeneImmunologyBiochemistrySTAT3Recombinant DNACytokine Signaling Pathways and InteractionsToxin Mechanisms and ImmunotoxinsImmune Cell Function and Interaction