Inhibition of SHP2 by the Small Molecule Drug SHP099 Prevents Lipopolysaccharide-Induced Acute Lung Injury in Mice
Shuhui Ye, Bowen Zuo, Lenan Xu, Yue Wu, Ruixiang Luo, Lin Ma, Wanxin Yao, Lingfeng Chen, Guang Liang, Yanmei Zhang
Topics & Concepts
LipopolysaccharideInflammationMedicineMAPK/ERK pathwaySepsisPharmacologyGene knockdownProtein tyrosine phosphataseCrosstalkPhosphorylationCancer researchImmunologyChemistryBiologyCell biologyApoptosisBiochemistryPhysicsOpticsProtein Tyrosine PhosphatasesNeutrophil, Myeloperoxidase and Oxidative MechanismsATP Synthase and ATPases Research