Disruption of KDM4C-ALDH1A3 feed-forward loop inhibits stemness, tumorigenesis and chemoresistance of gastric cancer stem cells
Tingyuan Lang, Jia Xu, Lei Zhou, Zhi‐Qi Zhang, Xinli Ma, Jiayi Gu, Jingshu Liu, Yunzhe Li, Dongyan Ding, Jiangfeng Qiu
Abstract
Gastric cancer (GC) is a considerable global health burden; the median survival of advanced GC is less than 1 year. 1 Cancer stem cells (CSCs), a small population of cancer cells with stem cell-like properties, are the major cause of treatment failure, including GC, 2 however, the mechanisms underlying stemness maintenance of GC stem cells (GCSCs) are still poorly understood.
Topics & Concepts
CarcinogenesisCancerCancer stem cellCancer researchStem cellBiologyCancer cellCell biologyGeneticsEpigenetics and DNA MethylationCancer Cells and MetastasisCancer-related gene regulation