Saikosaponin d modulates the polarization of tumor-associated macrophages by deactivating the PI3K/AKT/mTOR pathway in murine models of pancreatic cancer
Xinsheng Xu, Lihua Cui, Lanqiu Zhang, Lei Yang, Yuzhen Zhuo, Caixia Li
Topics & Concepts
PI3K/AKT/mTOR pathwayMacrophage polarizationCancer researchTumor microenvironmentProtein kinase BPancreatic cancerImmune systemChemistryMacrophageSignal transductionBiologyMedicineCancerImmunologyIn vitroCell biologyInternal medicineBiochemistryImmune cells in cancerGalectins and Cancer BiologyImmune Response and Inflammation