Exosomes from human adipose–derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-βR1/Smad axis
Liquan Wang, Tianhao Li, Xuda Ma, Yunzhu Li, Zhujun Li, Ziming Li, Nanze Yu, Jiuzuo Huang, Qin Han, Xiao Long
Topics & Concepts
Mesenchymal stem cellFibrosisMasson's trichrome stainMyofibroblastSMADChemistryWound healingAdipose tissuePathologyCancer researchTransforming growth factorCell biologyBiologyImmunologyMedicineBiochemistrySystemic Sclerosis and Related DiseasesConnective Tissue Growth Factor ResearchExtracellular vesicles in disease