Selection for Resistance to a Glyphosate-Containing Herbicide in Salmonella enterica Does Not Result in a Sustained Activation of the Tolerance Response or Increased Cross-Tolerance and Cross-Resistance to Clinically Important Antibiotics
Judith Pöppe, Katrin Bote, Abhinaya Ramesh, Jayaseelan Murugaiyan, Benno Kuropka, Michael Kühl, Paul R. Johnston, Uwe Roesler, Olga Makarova
Abstract
Glyphosate-based herbicides (GBH) are among the world's most popular, with traces commonly found in food, feed, and the environment. Such high ubiquity means that the herbicide may come into contact with various microorganisms, on which it acts as an antimicrobial, and it may select for resistance and cross-resistance to clinically important antibiotics. It is therefore important to estimate whether the widespread use of pesticides may be an underappreciated source of antibiotic-resistant microorganisms that may compromise efficiency of antibiotic treatments in humans and animals.
Topics & Concepts
Salmonella entericaGlyphosateAntibiotic resistanceSalmonellaBiologyCross-resistanceAntimicrobialResistance (ecology)Selection (genetic algorithm)BiotechnologyMicroorganismAntibioticsMicrobiologyBacteriaEcologyGeneticsArtificial intelligenceComputer sciencePesticide and Herbicide Environmental StudiesPharmaceutical and Antibiotic Environmental ImpactsWeed Control and Herbicide Applications