Selenomonas sputigena Interactions with Gingival Epithelial Cells That Promote Inflammation

Abstract

Increased prevalence and abundance of Selenomonas sputigena have been associated with periodontitis, a chronic inflammatory disease of tooth-supporting tissues, for more than 50 years. Over the past decade, molecular surveys of periodontal disease using 16S and shotgun metagenomic sequencing approaches have confirmed the disease association of classically recognized periodontal pathogens such as Porphyromonas gingivalis , Treponema denticola , and Tannerella forsythia while highlighting previously underappreciated organisms such as Filifactor alocis and S. sputigena .

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