Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis
Courtney Millar, Liya Anto, Chelsea Garcia, Mi‐Bo Kim, Anisha Jain, Anthony A. Provatas, Robert B. Clark, Ji‐Young Lee, Frank C. Nichols, Christopher N. Blesso
Abstract
were not observed. Therefore, we conclude that conditions in which gut microbiome-derived glycine lipids are lost, such as HFD, may exacerbate the development of atherosclerosis and liver injury, whereas correction of such depletion may protect from these disorders.
Topics & Concepts
GlycineLDL receptorSerineChemistryEndocrinologyInternal medicineIn vivoBiochemistryReceptorLipid metabolismAlanineBiologyAmino acidLipoproteinCholesterolMedicineEnzymeBiotechnologyGut microbiota and healthLiver Disease Diagnosis and TreatmentDiet and metabolism studies