Oxidative Kinetic Resolution of Cyclic Benzylic Ethers
Shutao Sun, Yingang Ma, Ziqiang Liu, Lei Liu
Abstract
)-H oxidation is reported. The practical approach is applicable to a wide range of 1,3-dihydroisobenzofurans bearing diverse functional groups and substituent patterns at the α position with extremely efficient enantiodiscrimination. The generality of the strategy was further demonstrated by efficient oxidative kinetic resolution of another type of five-membered cyclic benzylic ether, 2,3-dihydrobenzofurans, and six-membered 6H-benzo[c]chromenes. Direct late-stage oxidative kinetic resolution of bioactive molecules that are otherwise difficult to access was further explored.
Topics & Concepts
Kinetic resolutionChemistryOxidative phosphorylationKinetic energyResolution (logic)Organic chemistryCombinatorial chemistryComputational chemistryCatalysisEnantioselective synthesisBiochemistryComputer sciencePhysicsArtificial intelligenceQuantum mechanicsEnzyme Catalysis and ImmobilizationOxidative Organic Chemistry ReactionsAsymmetric Synthesis and Catalysis