Construction of unsymmetrical heterobiaryls <i>via</i> the Cp*Rh(<scp>iii</scp>)-catalysed C–H/C–H coupling of heteroarenes
Diksha Parmar, Tamanna Sharma, Akhilesh K. Sharma, Upendra Sharma
Abstract
Herein, a concise method for the Rh(III)-catalyzed, directing-group-assisted C-H/C-H cross-coupling of N-heterocycles (quinolines, indolines, indoles, pyridines, pyrimidines, pyrazoles) with other heteroarenes (benzoxazoles, benzofurans, and thiophenes) is disclosed for the synthesis of unsymmetrical heterobiaryl compounds in good to excellent yields. A plausible catalytic cycle has been delineated based on experimental and computational mechanistic studies.
Topics & Concepts
ChemistryCoupling (piping)StereochemistryMedicinal chemistryMaterials scienceComposite materialCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms