Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
Ruilin Tian, Anthony Abarientos, Jason Hong, Sayed Hadi Hashemi, Rui Yan, Nina M. Dräger, Kun Leng, Mike A. Nalls, Andrew Singleton, Ke Xu, Faraz Faghri, Martin Kampmann
Topics & Concepts
BiologyCRISPRTranscriptomeGeneCell typeNeurodegenerationGenomeGenome editingFunctional genomicsGene knockdownCell biologyComputational biologyCellGenomicsGeneticsGene expressionDiseaseMedicinePathologyCancer-related molecular mechanisms researchRNA Research and SplicingRNA modifications and cancer