m6A modification of circSPECC1 suppresses RPE oxidative damage and maintains retinal homeostasis
Xue Chen, Ying Wang, Jianan Wang, Qiu-Chen Cao, Ru-Xu Sun, Hong-Jing Zhu, Ye-Ran Zhang, Jiang-Dong Ji, Qinghuai Liu
Abstract
A modification and sponging miR-145-5p, resists oxidative stress injuries and maintains lipid metabolism in RPE. Pharmacological supplementation of circSPECC1 is a promising therapeutic option for atrophic retinopathies like AMD.
Topics & Concepts
Retinal pigment epitheliumOxidative stressMacular degenerationRetinalGene silencingCell biologyRetinal degenerationHomeostasisBiologyRetinaLipid metabolismPopulationInternal medicineEndocrinologyNeuroscienceMedicineBiochemistryOphthalmologyGeneEnvironmental healthRNA modifications and cancerinterferon and immune responsesCancer-related molecular mechanisms research