A miniprotein receptor electrochemical biosensor chip based on quantum dots
Yunong Zhao, Juan Han, Jing‐Kai Huang, Qing Huang, Yanbing Tao, Ruiqin Gu, Hua‐Yao Li, Yang Zhang, Houjin Zhang, Huan Liu
Abstract
(0.013 fM for the HEMT device). Due to the high sensitivity of the electrochemical biosensor, it was also used to study the binding kinetics between the unnatural receptor LCB and spike protein, which has achieved comparable results as those obtained with commercial equipment. To the best of our knowledge, this is the first example of using a computationally designed miniprotein receptor based on electrochemical methods, and it is the first kinetic assay performed with an electrochemical assay alone. The miniprotein receptor electrochemical biosensor based on QDs is desirable for fabricating high-throughput, large-area, wafer-scale biochips.