Ultrathin functionalized covalent organic framework nanosheets for tumor-targeted photodynamic therapy
Peng Gao, Ruyue Wei, Bingjie Cui, Xiaohan Liu, Yuanyuan Chen, Wei Pan, Na Li, Bo Tang
Abstract
We developed a modification-facilitated exfoliation strategy for the one-step preparation of ultrathin 2D functionalized covalent organic framework nanosheets (COF NSs). Hyaluronic acid-functionalized ultrathin porphyrin COF NSs (about 5-8 nm) with enhanced reactive oxygen species (ROS) generation effect were readily prepared for tumor-targeted photodynamic therapy.
Topics & Concepts
Photodynamic therapySurface modificationCovalent bondExfoliation jointNanotechnologyMaterials scienceCombinatorial chemistryChemistryOrganic chemistryGraphenePhysical chemistryNanoplatforms for cancer theranosticsCovalent Organic Framework ApplicationsLuminescence and Fluorescent Materials