BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments
Sudipta Lahiri, George L. Hamilton, Gemma Moore, Liana Goehring, Tony T. Huang, Ryan B. Jensen, Eli Rothenberg
Topics & Concepts
RAD51PARP1ChemistryMedicineHomologous recombinationPoly ADP ribose polymeraseDNABiochemistryPolymerasePARP inhibition in cancer therapyDNA Repair MechanismsCRISPR and Genetic Engineering