High-salt diet augments systolic blood pressure and induces arterial dysfunction in outbred, genetically diverse mice
Xiangyu Zheng, Jennifer Berg Sen, Zhuoxin Li, Mostafa Sabouri, Luaye Samarah, Christina Deacon, Joseph Bernardo, Daniel R. Machin
Abstract
Excess salt consumption is a contributor to hypertension and arterial dysfunction in humans living in industrialized societies, but this phenotype is not observed in inbred, genetically identical mice that consume a high-salt (HS) diet. This study reveals that a HS diet in outbred, genetically diverse mice progressively increases systolic blood pressure and induce arterial dysfunction. These data suggest that genetically diverse mice may provide translational insight into arterial adaptations in humans that consume an HS diet.
Topics & Concepts
Blood pressureGenetically modified organismPhenotypeDietary saltInternal medicineInbred strainMedicineBiologyEndocrinologyGeneGeneticsSodium Intake and HealthRenin-Angiotensin System StudiesHormonal Regulation and Hypertension