Regenerative potential of Wharton's jelly‐derived mesenchymal stem cells: A new horizon of stem cell therapy
Hossein Abbaszadeh, Farzaneh Ghorbani, Mehdi Derakhshani, Ali Akbar Movassaghpour, Mehdi Yousefi, Mehdi Talebi, Karim Shamsasenjan
Abstract
Umbilical cord Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have recently gained considerable attention in the field of regenerative medicine. Their high proliferation rate, differentiation ability into various cell lineages, easy collection procedure, immuno-privileged status, nontumorigenic properties along with minor ethical issues make them an ideal approach for tissue repair. Besides, the number of WJ-MSCs in the umbilical cord samples is high as compared to other sources. Because of these properties, WJ-MSCs have rapidly advanced into clinical trials for the treatment of a wide range of disorders. Therefore, this paper summarized the current preclinical and clinical studies performed to investigate the regenerative potential of WJ-MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.