The CRISPR-Cas System Differentially Regulates Surface-Attached and Pellicle Biofilm in Salmonella enterica Serovar Typhimurium
Nandita Sharma, Ankita Das, Pujitha Raja, Sandhya Amol Marathe
Abstract
In addition to being implicated in bacterial immunity and genome editing, the CRISPR-Cas system has recently been demonstrated to regulate endogenous gene expression and biofilm formation. While the function of individual cas genes in controlling Salmonella biofilm has been explored, the regulatory role of CRISPR arrays in biofilm is less studied.
Topics & Concepts
BiofilmSalmonella entericaMicrobiologyDownregulation and upregulationBiologyCRISPRMutantGeneLipopolysaccharideOperonGene knockoutRegulation of gene expressionCell biologyBacteriaEscherichia coliGeneticsEndocrinologyCRISPR and Genetic EngineeringBacterial biofilms and quorum sensingVibrio bacteria research studies