GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats
Samantha M. Fortin, Rachele K. Lipsky, Rinzin Lhamo, Jack Chen, Eun Kyung Kim, Tito Borner, Heath D. Schmidt, Matthew R. Hayes
Abstract
transcripts in NTS GABAergic neurons, which when inhibited using chemogenetics, attenuated the food intake- and body weight-reducing effects of liraglutide. This work demonstrates the contribution of NTS GLP-1Rs to the anorectic potential of liraglutide and highlights a phenotypically distinct (GABAergic) population of neurons within the NTS that express the GLP-1R and are involved in the mediation of liraglutide signaling.
Topics & Concepts
LiraglutideAnorecticArea postremaSolitary nucleusEndocrinologyInternal medicineAgonistMedicineGlucagon-like peptide-1HypothalamusReceptorHindbrainNeuroscienceCentral nervous systemBiologyFood intakeDiabetes mellitusType 2 diabetesRegulation of Appetite and ObesityNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones