Cytoskeleton Organization in Formation and Motility of Apicomplexan Parasites
Ross G. Douglas, Robert W. Moon, Friedrich Frischknecht
Abstract
Apicomplexan parasites are a group of eukaryotic protozoans with diverse biology that have affected human health like no other group of parasites. These obligate intracellular parasites rely on their cytoskeletal structures for giving them form, enabling them to replicate in unique ways and to migrate across tissue barriers. Recent progress in transgenesis and imaging tools allowed detailed insights into the components making up and regulating the actin and microtubule cytoskeleton as well as the alveolate-specific intermediate filament–like cytoskeletal network. These studies revealed interesting details that deviate from the cell biology of canonical model organisms. Here we review the latest developments in the field and point to a number of open questions covering the most experimentally tractable parasites: Plasmodium , the causative agent of malaria; Toxoplasma gondii , the causative agent of toxoplasmosis; and Cryptosporidium , a major cause of diarrhea.