Use of CRISPR/Cas9 gene editing to improve chimeric antigen-receptor T cell therapy: A systematic review and meta-analysis of preclinical studies
Harinad B. Maganti, Aidan M. Kirkham, Adrian Bailey, Risa Shorr, Natasha Kekre, Nicolas Pineault, David Allan
Topics & Concepts
Chimeric antigen receptorCRISPRGenome editingGenetic enhancementCas9BiologyImmune systemCancerMelanomaLeukemiaImmunotherapyCancer researchImmunologyGeneComputational biologyMedicineGeneticsCAR-T cell therapy researchCRISPR and Genetic EngineeringVirus-based gene therapy research