Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)-induced dissecting abdominal aortic aneurysm
Hao Li, Haochen Xu, Hongyan Wen, Hongyue Wang, Ranxu Zhao, Yingying Sun, Congxia Bai, Jiedan Ping, Li Song, Mingyao Luo, Jingzhou Chen
Abstract
LH1 deficiency contributes to dissecting AAA pathogenesis, at least in part, by upregulating thrombospondin-1 expression, which subsequently enables proinflammatory processes, MMP activation and VSMCs apoptosis. Our study provides evidence that LH1 is a potential critical therapeutic target for AAA.
Topics & Concepts
Angiotensin IIThrombospondinThrombospondin 1PathogenesisElastinExtracellular matrixProinflammatory cytokineAbdominal aortic aneurysmMatrix metalloproteinaseChemistryVascular smooth muscleEndocrinologyMedicineInternal medicineMetalloproteinaseInflammationPathologyBiochemistryAneurysmAngiogenesisReceptorSurgerySmooth muscleAortic aneurysm repair treatmentsAortic Disease and Treatment ApproachesConnective tissue disorders research