Lewis Acid-Mediated Deoxygenative Synthesis of Trivalent Sterically Hindered Phosphines from Aldehydes
Xiaoqiang Wu, Abuduwaili Alimu, Wei Zhong, Tao Xu
Abstract
The efficient synthesis of trisubstituted trivalent phosphines remains challenging. Herein, we report a novel approach for rapid construction of these compounds from aldehydes under Lewis acid-mediated conditions. By using sterically hindered disubstituted phosphines, aldehydes can undergo a deoxygenative reaction to afford trivalent phosphorus compounds. This modular and practical method is characterized by operational simplicity, a broad substrate scope, and excellent functional group tolerance, which holds great potential for applications in organic synthesis.
Topics & Concepts
ChemistrySteric effectsLewis acids and basesCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalysisOrganophosphorus compounds synthesisAsymmetric Hydrogenation and CatalysisChemical Synthesis and Analysis