Litcius/Paper detail

Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment

D. Lucas Kerr, Franziska Haderk, Trever G. Bivona

2021Current Opinion in Chemical Biology123 citationsDOI

Topics & Concepts

Allosteric regulationDruggabilityCancer researchReceptor tyrosine kinaseMAPK/ERK pathwayKinaseTumor microenvironmentBiologyReceptorCell biologyBiochemistryTumor cellsGeneProtein Tyrosine PhosphatasesGalectins and Cancer BiologyCytokine Signaling Pathways and Interactions
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment | Litcius