Activation of the NLRP3 Inflammasome by Particles from the Echinococcus granulosus Laminated Layer
Cecilia Casaravilla, Álvaro Pittini, Dominik Rückerl, Judith E. Allen, Álvaro Díaz
Abstract
The interaction of dendritic cells and macrophages with a variety of rigid noncellular particles triggers activation of the NLRP3 inflammasome and consequent secretion of interleukin 1β (IL-1β). Noncellular particles can also be generated in the context of helminth infection, since these large pathogens often shed their outermost structures during growth and/or molting. One such structure is the massive, mucin-based, soft, flexible laminated layer (LL), which protects the larval stages of cestodes of the genus Echinococcus .
Topics & Concepts
InflammasomeBiologyContext (archaeology)SecretionEchinococcus granulosusCell biologyMucinMicrobiologyImmunologyInflammationZoologyBiochemistryPaleontologyParasitic infections in humans and animalsCongenital Anomalies and Fetal SurgeryAmoebic Infections and Treatments