<i>Propionibacterium freudenreichii</i> CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening
Marine Mantel, Tony Durand, Anne Bessard, Ségolène Pernet, Julie Beaudeau, Juliana Guimarães Laguna, Marie-Bernadette Maillard, Éric Guédon, Michel Neunlist, Yves Le Loir, Gwénaël Jan, Malvyne Rolli‐Derkinderen
2023American Journal of Physiology-Gastrointestinal and Liver Physiology12 citationsDOIOpen Access PDF
Abstract
Propionibacterium freudenreichii reduces dextran sodium sulfate (DSS)-induced intestinal permeability in vivo . P. freudenreichii does not inhibit inflammation but damages linked to inflammation. P. freudenreichii inhibits intestinal epithelial breakdown through S-layer protein B. The protective effects of P. freudenreichii depend on S-layer protein B. Extracellular vesicles from P. freudenreichii CB 129 mimic the protective effect of the probiotic.
Topics & Concepts
Propionibacterium freudenreichiiIntestinal permeabilityExtracellularChemistryInflammationMicrobiologyBiologyBiochemistryImmunologyFermentationProbiotics and Fermented FoodsGut microbiota and healthPolysaccharides and Plant Cell Walls